Pathophysiology of Drug-Induced Dyskinesias
نویسندگان
چکیده
Christopher A. Lieu1,2, Vikram Shivkumar1, Timothy P. Gilmour1,2, Kala Venkiteswaran1,2, Mark J. Nolt1,3, Milind Deogaonkar4 and Thyagarajan Subramanian1,2 1Department of Neurology, The Pennsylvania State University College of Medicine and M.S. Hershey Medical Center, Hershey, Pennsylvania 2Department of Neural & Behavioral Sciences, The Pennsylvania State University College of Medicine and M.S. Hershey Medical Center, Hershey, Pennsylvania 3Functional Neurosurgical Services, Sentient, Inc., Hunt Valley, Maryland 4Center for Neurological Restoration, The Cleveland Clinic Foundation, Cleveland, Ohio USA
منابع مشابه
Clinical Features, Pathophysiology, and Treatment of Levodopa-Induced Dyskinesias in Parkinson's Disease
Dyskinetic disorders are characterized by excess of motor activity that may interfere with normal movement control. In patients with Parkinson's disease, the chronic levodopa treatment induces dyskinetic movements known as levodopa-induced dyskinesias (LID). This paper analyzed the pathophysiology, clinical manifestations, pharmacological treatments, and surgical procedures to treat hyperkineti...
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Two young children, 5 and 30 months of age, developed acute transient dyskinesias. The novel features of these patients were classic orobuccal-lingual dyskinesias, their young ages, and the association with asthma and theophylline. The movements resembled tardive dyskinesias of older patients on neuroleptics, but neither patient had any exposure to neuroleptic drugs. Choreiform movements were m...
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The aim of this work was to study the role of subthalamo-pallidal synchronisation in the pathophysiology of dyskinesias. We recorded local field potentials (LFPs) in a patient with Parkinson's disease and left surgery induced dyskinesias with double, bilateral deep brain stimulation electrode implants in the subthalamic nucleus (STN) and the globus pallidus internus (GPi). Synchronisation was s...
متن کاملPresynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats.
Drug-induced dyskinesias in dopamine-denervated animals are known to depend on both pre- and postsynaptic changes of the nigrostriatal circuitry. In lesion models used thus far, changes occur in both of these compartments and, therefore, it has not been possible to dissect the individual contribution of each compartment in the pathophysiology of dyskinesias. Here we silenced the nigrostriatal d...
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BACKGROUND Dyskinesias are a frequent adverse effect of long-term levodopa therapy. The relative contribution of dopamine D(1) and D(2) receptor function to the pathophysiology of levodopa-induced dyskinesias remains a matter of controversy. OBJECTIVE To establish whether a selective D(1) dopamine agonist induces more or less dyskinesia than levodopa in primed dyskinetic patients with Parkins...
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